for the treatment of severe joint pain is used tramadol

Introduction - tramadol

tramadol is used for relieving moderate to moderately severe pains. The drug also can be used for treating the pain caused because of any surgeries and/or chronic conditions like cancer or severe joint pain. The drug tramadol works by decreasing the brain's perceptions and responses to the pain occurring on any site of the body. The drug also reduces the severity or intensity of the pain signal that is passing from one nerve to another. The medication is oftentimes prescribed for treating some other health ailments and adverse conditions. However, you have to ask a doctor or pharmacist for more information.

Drug Interactions

In vitro studies indicate that tramadol is unlikely to inhibit the CYP3A4-mediated metabolism of other drugs when tramadol is administered concomitantly at therapeutic doses. tramadol does not appear to induce its own metabolism in humans, since observed maximal plasma concentrations after multiple oral doses are higher than expected based on single-dose data. tramadol is a mild inducer of selected drug metabolism pathways measured in animals.

Use With Carbamazepine: Patients taking carbamazepine may have a significantly reduced analgesic effect of tramadol hydrochloride. Because carbamazepine increases tramadol metabolism and because of the seizure risk associated with tramadol, concomitant administration of tramadol hydrochloride and carbamazepine is not recommended.

Use With Quinidine: tramadol is metabolized to M1 by CYP2D6. Quinidine is a selective inhibitor of that isoenzyme, so that concomitant administration of quinidine and tramadol hydrochloride results in increased concentrations of tramadol and reduced concentrations of M1. The clinical consequences of these findings are unknown. In vitro drug interaction studies in human liver microsomes indicate that tramadol has no effect on quinidine metabolism.

Use With lnhibitors of CYP2D6: In vitro drug interaction studies in human liver microsomes indicate that concomitant administration with inhibitors of CYP2D6 such as fluoxetine, paroxetine, and amitriptyline could result in some inhibition of the metabolism of tramadol.

Use With Cimetidine: Concomitant administration of tramadol hydrochloride with cimetidine does not result in clinically significant changes in tramadol pharmacokinetics. Therefore, no alteration of the tramadol hydrochloride dosage regimen is recommended.

Use With MAO Inhibitors: Interactions with MAO Inhibitors, due to interference with detoxification mechanisms, have been reported for some centrally acting drugs (see WARNINGS, Use With MAO Inhibitors).

Use With Digoxin And Warfarin: Post-marketing surveillance has revealed rare reports of digoxin toxicity and alteration of warfarin effect, including elevation of prothrombin times.

Source : http://buyultram.com/articles/drug-interactions-of-tramadol.html
Severe Joint Pain? Try tramadol